Therapeutic effect of chloroquine(CQ)-containing immunoliposomes in rats infected with Plasmodium berghei parasitized mouse red blood cells: comparison with combinations of antibodies and CQ or liposomal CQ
Identifieur interne : 003110 ( Main/Exploration ); précédent : 003109; suivant : 003111Therapeutic effect of chloroquine(CQ)-containing immunoliposomes in rats infected with Plasmodium berghei parasitized mouse red blood cells: comparison with combinations of antibodies and CQ or liposomal CQ
Auteurs : Pierre A. M. Peeters [Pays-Bas] ; Bardo G. Brunink [Pays-Bas] ; Wijnand M. C. Eling [Pays-Bas] ; Daan J. A. Cromelin [Pays-Bas]Source :
- BBA - Biomembranes [ 0005-2736 ] ; 1989.
English descriptors
- Teeft :
- Agglutinate mrbc, Blood cell, Blood cells, Blood compartment, Blood smears, Blood stream, Complete medium, Control lipcq, Days period, Density centrifugation, Diethyl ether, Drug deliv, Equal protein concentration, Free parasites, Further study, High level, Host cell, Immunoliposomes, Independent experiments, Infection, Intravenous infection, Lipcq, Liposome, Lower ratios, Merozoite, Microscopic analysis, Mrbc, Organ distribution, Parasite, Parasitemia, Parasitized, Parasitized mouse, Particle size, Patency, Patent infection, Phospholipid, Positive animal, Positive rats number, Present study, Previous experiments, Rat, Reaction medium, Reticulocyte, Similar clearance curves, Swiss mice, Tail vein, Target cells, Therapeutic effect, Therapeutic efficacy, Therapeutic efficiency, Total amount, Total volume, Vivo model, White blood cells, Whole blood.
Abstract
Abstract: The potential therapeutic application of chloroquine-containing immunoliposomes (Fab′-lipCQ) in a Plasmodium berghei malaria model was studied. Extending a previously described in vivo model (Peeters et al. (1988) Biochim. Biophys. Acta 943, 137–147) it was demonstrated that injection of antimouse red blood cell (anti-mRBC) Fab′-lipCQ was significantly more effective than liposome-encapsulated chloroquine (lipCQ) or free chloroquine in delaying or preventing a patent infection after intravenous injection of parasitized mouse red blood cells (p-mRBC) in rats. The results could be improved by injecting synchronized infected cells instead of non-synchronous p-mRBC in order to minimize the presence of free parasites which could easily infect rat RBC. It was further demonstrated that sequential injection of anti-mRBC IgG and lipCQ or chloroquine resulted in complete inactivation of the injected parasitized cells while Fab′-lipCQ administration resulted in a maximum score of 50% at an equal chloroquine, protein and phospholipid dose. In this report the potential of the concept of drug targeting for the effective treatment of a disease, which manifests in blood cells, was demonstrated.
Url:
DOI: 10.1016/0005-2736(89)90037-0
Affiliations:
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Extending a previously described in vivo model (Peeters et al. (1988) Biochim. Biophys. Acta 943, 137–147) it was demonstrated that injection of antimouse red blood cell (anti-mRBC) Fab′-lipCQ was significantly more effective than liposome-encapsulated chloroquine (lipCQ) or free chloroquine in delaying or preventing a patent infection after intravenous injection of parasitized mouse red blood cells (p-mRBC) in rats. The results could be improved by injecting synchronized infected cells instead of non-synchronous p-mRBC in order to minimize the presence of free parasites which could easily infect rat RBC. It was further demonstrated that sequential injection of anti-mRBC IgG and lipCQ or chloroquine resulted in complete inactivation of the injected parasitized cells while Fab′-lipCQ administration resulted in a maximum score of 50% at an equal chloroquine, protein and phospholipid dose. In this report the potential of the concept of drug targeting for the effective treatment of a disease, which manifests in blood cells, was demonstrated.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Gueldre</li><li>Utrecht (province)</li></region><settlement><li>Nimègue</li><li>Utrecht</li></settlement></list><tree><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Peeters, Pierre A M" sort="Peeters, Pierre A M" uniqKey="Peeters P" first="Pierre A. M." last="Peeters">Pierre A. M. Peeters</name></region><name sortKey="Brunink, Bardo G" sort="Brunink, Bardo G" uniqKey="Brunink B" first="Bardo G." last="Brunink">Bardo G. Brunink</name><name sortKey="Cromelin, Daan J A" sort="Cromelin, Daan J A" uniqKey="Cromelin D" first="Daan J. A." last="Cromelin">Daan J. A. Cromelin</name><name sortKey="Eling, Wijnand M C" sort="Eling, Wijnand M C" uniqKey="Eling W" first="Wijnand M. C." last="Eling">Wijnand M. C. 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